How much phenobarbital can a dog take?

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How much phenobarbital can a dog take?

The initial dosage (dogs only) is 5–15 mg/kg/day in three divided doses, increased over time to a maximum of 35 mg/kg/day. Effective serum levels are determined by the serum level of phenobarbital (15–45 mcg/mL).

What happens if you give a dog too much phenobarbital?

Increased appetite, which may lead to weight gain. Increased thirst and urination. Anxiety. Anemia.

How much Phenobarbital is too much?

In general, an oral dose of 1 gram of most barbiturates produces serious poisoning in an adult. Death commonly occurs after 2 to 10 grams of ingested barbiturate.

How long does it take for a dog to adjust to phenobarbital?

Phenobarbitone is often the preferred first choice as it takes effect more quickly (within 2 weeks) than Potassium Bromide (3 to 6 months).

How bad is phenobarbital for dogs?

Common side effects in dogs include anxiety, agitation, lethargy, or sedation when therapy is started, and increased thirst, urination, and appetite or elevated liver enzymes on bloodwork are possible. Side effects such as incoordination may indicate a dose that is too high.

How do you stop phenobarbital in dogs?

How to stop phenobarbital or potassium bromide? It should be done very gradually to avoid withdrawal seizures. Evaluate the serum levels before. If the levels are well within therapeutic range (above 90 umol/L), a minimum of 16 weeks is necessary (usually 6 to 18 months).

Can phenobarbital cause liver damage in dogs?

Long-term administration of phenobarbital has been reported to cause hepatic injury in dogs. Phenobarbital induces hepatic enzymes, and it may be difficult to distinguish the effect of enzyme induction on serum liver enzyme activities from actual hepatic damage.

Do you need to wean off phenobarbital?

Phenobarbital therapy may be successfully discontinued in elderly patients, particularly when there is no clear indication for its use. When discontinuing phenobarbital therapy, tapering is recommended to avoid the signs and the symptoms of phenobarbital withdrawal.

How long does it take to wean off phenobarbital?

Smith and Wesson [8] observed that symptoms, such as anxiety, insomnia, and paresthesia, after withdrawal from low-dose benzodiazepine typically take 6–12 months to subside completely.

What type of seizure is phenobarbital used for?

Phenobarbital is useful in controlling simple and complex partial seizures and generalized tonic-clonic seizures in children. It has traditionally been considered the first choice to treat neonatal seizures (seizures in newborn infants).

What are the side effects of phenobarbital?

Phenobarbital may cause side effects. Call your doctor if any of the following symptoms are severe or do not go away:

  • drowsiness.
  • headache.
  • dizziness.
  • excitement or increased activity (especially in children)
  • nausea.
  • vomiting.

Is there a substitute for phenobarbital?

In our experience, clorazepate is a moderately effective alternative anticonvulsant drug. In dogs already receiving phenobarbital, maintaining the correct dosage of clorazepate can be troublesome.

What does a seizure look like in a dog sleeping?

Dogs experiencing a seizure cannot be easily woken, while dreaming dogs can. Dogs having a seizure often are disoriented afterwards and may drool and pant. Seizing dogs may urinate or defecate on themselves, while dreaming dogs usually do not.

Ben Wills

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